A collision and truck rollover at Porepunkah on Wednesday morning saw a driver flown to hospital and another hospitalised.
A Victoria Police spokesperson said emergency services responded to the incident around 8:40am after receiving reports a truck had clipped another vehicle before rolling on the Great Alpine Road.
The truck driver was airlifted to hospital with non-life threatening injuries while the driver of the second vehicle was hospitalised for observation.
An Ambulance Victoria spokesperson said the truck driver sustained serious lower body injuries while the other driver was taken to Wangaratta in a stable condition.
The exact circumstances surrounding the collision are yet to be determined and police investigations remain ongoing.
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Anyone with information that could assist police is urged to contact Crime Stoppers on 1800 333 000 or submit a confidential report online at www.crimestoppersvic.com.au