A man was seriously injured following a truck crash on the Murray Valley Highway at Browns Plains Wednesday morning.

An Ambulance Victoria spokesperson said Advanced Life Support and Mobile Intensive Care Ambulance paramedics attended the scene near the Chiltern-Howlong Road intersection just before 11:30am.

A man in his 20s was treated for serious lower body injuries and taken to Albury Base Hospital in stable condition.

The Department of Transport and Planning issued a traffic alert advising motorists the highway was closed between Chiltern-Howlong Road and Barnawartha-Howlong Road.

Motorists were advised to avoid the area and detour around the site via Barnawartha-Howlong Road and Chiltern-Howlong Road.