A girl has died after a head-on collision on the Hume Freeway at Wodonga in the early hours of Friday morning.

A Victoria Police spokesperson said it was believed a stolen Nissan X-Trail, driven by an 18-year-old Corryong woman with a 16-year-old passenger from the Wodonga area, collided head-on with a utility about 12:50am.

The 18-year-old was taken to hospital with non-life-threatening injuries, but the 16-year-old passenger died at the scene.

Driver of the ute, a 23-year-old NSW man, was taken to hospital with non-life-threatening injuries.

The police spokesperson said investigators allege the Nissan was stolen from a West Wodonga address on 30 September.

Major Collision Investigation Unit detectives are investigating the circumstances of the collision.

Any witnesses or anyone with dashcam footage is urged to contact Crime Stoppers on 1800 333 000 or submit a confidential report online at www.crimestoppersvic.com.au

The deadly collision followed two other fatal road incidents in the North East over the past few days.

A 45-year-old Nathalia woman died after a head-on collision in Kaarimba on Thursday afternoon, while a 30-year-old man was airlifted to hospital with serious injuries.

It’s believed a Toyota Corolla collided with a Renault SUV on Barmah-Shepparton Road just after 4.30pm.

In Wangaratta, a truck driver died after a fiery crash into two parked trucks at the South Wangaratta Hume Freeway rest area in the early hours of Wednesday morning.

Police continue to investigate both incidents.